The University of Alaska Fairbanks closed its nanotechnology office on Wednesday, which neatly illustrates the problem of setting up a centre without giving much though to its purpose. Even those involved in the project didn’t seem to have much idea what they were doing and even what nanotechnology was…

But nanotechnology was a tough field to break into, especially since Outside competitors already had a head start in the study of ultra-tiny circuits and microchips. An early director of the office, Pramod Karulkar, expressed enthusiasm for the program’s potential in a 2004 UAF press release while admitting that “this endeavor is unusual for Alaska and appears risky.”

“It was a challenge from the start, because there were always competitors in this field, and we were kind of starting from ground zero,” Grimes said.

I have to admit to feeling some sadness when I saw this
The Office of Electronic Miniaturization, which was established in 2001, was envisioned as a hub for creating products in the emerging field of microscopic technology. But instead of producing commercially viable inventions, the OEM migrated toward basic research.

Its a sad story and not confined to nanotechnology – many science parks have suffered the same fate, with constructing shiny new office buildings taking precedence over evaluating whether there is any demand. As one researcher told me over a beer in Spain almost ten years ago “nobody wants or needs this new science park, but the regional government wants to build it instead of new academic buildings. After a few years we’ll be able to use it as new offices and lab space anyway.”

 
nanotech underpants?

What's In Your Underwear?

I bet you were expecting these to be stain resistant too, but the key application of nanotech underwear is medical sensing according to Business Week.

The tight elastic waistband of underwear “has tight contact and direct exposure with the skin and it allows for direct sweat monitoring via the chemical-sensing electrodes. And it seems elastic is a hardy textile. Engineers at the University of California, San Diego Jacobs School of Engineering discovered that even after aggressive testing by stretching, folding and pulling, the chemical sensors printed on the elastic still retained their sensing ability and could detect hydrogen peroxide and NADH — two compounds that sensors in “smart’ systems will need to recognize.”

According to Professor Joseph Wang, from the Department of NanoEngineering at the University of California,

If, for example, an injured soldier went into shock, enzymes on the electrode would sense rising levels of the biomarkers lactate, glucose and norepinephrine. This would cause the concentrations of products generated by the enzymes to change — higher hydrogen peroxide, lower norepi-quinone, higher NADH and lower NAD+. This would cause the built-in logic structure to output the signal “1,0,1,0″ which indicates shock and could trigger a pre-determined treatment response.

The obvious problem seems to be how to transmit the data back to base without constantly bathing ones reproductive parts in microwave radiation, and of course keeping any medical supplies fresh in what is a notoriously warm and humid part of the anatomy.

Still, it should make an interesting and amusing change after sitting though years of conference speakers demonstrating the stain resistant properties of nanotech textiles using a glass of red wine (and sometimes ruining a carpet in the process).

 

Migrating Buckyballs

Luna's Trimetaspheres

Arrowhead Research announced today that it had sold off the IP of one of its subsidiaries, Tego, to Luna Innovations in exchange for $430,000 less legal and transaction fees in exchange for a cut of any proceeds. Luna of course have been looking at buckyballs for improved MRI contrast agents – careful here! it’s a tricky subject –  for quite a while using the wonderfully named trimetaspheres.

The basic idea is great. You can take a nasty toxic substance such as gadolinium that happens to show up very well in MRI scans, and encase it in a fullerene cage so that all the patients body sees is carbon. However as with much to do with fullerenes, producing anything that works at a cost that is even vaguely competitive tends to be far tougher that originally envisaged.

So what we are seeing is an ongoing migration of various bits of nanotech IP towards companies that can turn them into a useful application. This particular bit of IP came from Carbon Nanotechnologies Inc whose plans for global domination included hoovering up every bit of carbon related IP they could fund and worrying what to do with it later.

 

Within weeks of nanotechnology becoming hot news, most of the nanotech related top level domains had been snapped in the expectation that a trillion dollar industry would emerge faster than you could say dot.com. Bored with waiting for a pay off, many are now up for grabs. The folks at nanovip.com are unloading their list of hopefuls after failing to attract any interest in nanosuccess.com. Anyone wanting a nano brand or domain will already have one by now, and it looks so 2001! The full list is here.

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The Wall Street Journal points to further evidence of the collapse of Venture Capital.  Typical of the doom laden quotes is this:

“Dallas is an entrepreneurial city, but it won’t be driven by venture capital going forward,” said Daniel T. Owen, a venture capitalist at the 16th-floor firm H02 Partners, which plans to wind down its venture business over the next few years. “The pure venture-capital model is really thriving in just Silicon Valley and Boston.”

The bottom line is, in this case the bottom line, as VCs who haven’t managed to make any money for their investors are left bemused by the unwillingness of anyone else to hand over cash. I’m bemused as to whether that’s an arrogant or stupid view of the world.

Toto, This isn’t 1997 any more!

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Nature published an interesting paper at the weekend, a Canadian meta study into public attitudes to nanotechnology. The key finding is that “those who perceive greater benefits outnumber those who perceive greater risks by 3 to 1.” That’s probably not too surprising, as the majority of press stories about nanotechnology tend to be along the lines of it curing cancer or making things better and/or more useful, but it’s nice to have some confirmation of this.

Michael Todd has some more thoughts on this, with the usual headline that the results are ‘surprising’ – I’m not sure that they are.

The researchers also found that “a large minority of those surveyed (44%) is unsure” – which once again correlates with my London based experience which suggests that around 50% of people who work in electrical superstores or man call centres don;t have a clue what they are talking about, but manage to form an opinion nonetheless (the exception to this rule seems to be builders and plumbers merchants who not only know exactly what they are talking about but show Herculean patience when dealing with lesser mortals.)

In a nutshell then, people don’t mind nanotechnology, or any other technology too much if they perceive that it will have a positive impact on their daily lives, and will put up with a modicum of risk in order to enjoy the benefits. A bit like a chicken crossing the road then.

 

With a heavy heart I predicted a few high profile nanotechnology failures this year, and Evident Technologies are the latest to file for Chapter 11 bankruptcy protection. In common with Oxonica, Evident found themselves in a patent infringement fight with someone with deeper pockets then them, in this case Life Technologies (formerly Invitrogen) who got into the business by acquiring Quantum Dot Corporation back in 2005. The court costs were so high it pushed Evident over the edge. Losing their CEO earlier in the year probably didn’t help either.

There’s a nice contrast between the two litigants here, and one that illustrates the problems involved in getting a technology to market. In the case of the troubled companies, Oxonica and Evident, the strategy was based on first figuring out how to produce a nanomaterial and then trying to find a market for it. While both companies have made sales, neither has ever had quite enough volume to cross the chasm and become a sustainable business. Life Technologies, in contrast, pursued an acquisition strategy that netted them entry to other markets, and nanotechnology is just a part of their business rather than the whole of it.

There is a valuable lesson here, which is to start with the market, not the technology. In the early stages of a technology when investors are bullish a technology led strategy may work, but diversifying as quickly as possible is the key to survival.

 

It’s interesting that IBM seems to be the partner of choice for a number of nanotechnology in emerging economies such as Bulgaria and Egypt, (where there are large number of vacancies, including the post of “Centre Director.”)

IBM, as we all know, was responsible for the STM/AFM and holds a wide variety of nanotechnology related patents, including some fairly fundamental ones on carbon nanotubes. Partnering with these new centers allows IBM to double dip by providing services (now the core business) and encourage the exploitation of its patents – something that looks like a pretty smart strategy to me.

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Zettacore Change Tack

Interesting to see Zettacore raising a $21m series C, some six years after they first started our promising to replace silicon with molecular memories, although that’s not the application that is attracting interest right now.

As Nikkei Electronics reported last week – they look to have a customer for their Molecular Interface (aren’t most interfaces molecular?) technology that helps with conventional semiconductor manufacturing. While their initial plan for global domination of the memory business seems to have been elbowed aside with the fall in price of flash memory from a dollar a Mb 2001 to less than a dollar a Gb 2009, the R&D does seem to have been useful for something…

ZettaCore said MI technology enables deposition of copper on smooth dielectric, and lamination of dielectric on smooth copper in high-performance IC substrates, HDI boards, high-speed boards, flexible PCBs, and wafer level packaging. Since surface roughening is eliminated, customers can realize finer line/space dimensions and improve signal integrity while using conventional materials and processes.

“ZettaCore MI technology offers IC substrate customers the ability to leverage their manufacturing infrastructure and yet realize finer line/space design rules. For example, customers can advance interconnect geometries with the current GX-13 material beyond what is possible with conventional roughening technologies. Since the interfaces are smooth, losses related to skin effect are minimized which would improve system performance,” said Takao Sakurai, general manager of Specialty Chemical Dept, Ajinomoto Co Inc.

By working with Ajinomoto, ZettaCore is offering a complete and seamless solution to substrate manufacturers.

“Ajinomoto GX-13 build-up resin has a dominant market share in flip-chip IC substrates. Customers can now realize 10µm line/space design rules and beyond by using ZettaCore MI technology in conjunction with GX-13 material,” said Srinivas Nimmagadda, VP of Business Development at ZettaCore.

That’s another set of rebels assimilated into the world of CMOS then.

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An interesting battle is brewing over the hydrogen economy with the Obama administration doubting that fuel cells will make much of a difference over the next ten years to be worth funding and describing the decision as a reduction of “less effective programs so we can invest in our economic future.”

Honda, Toyota & General Motors have grumbled bitterly about this as all three have invested heavily in fuel cell research and have a vested interest in the US Government putting up the billions needed to develop a hydrogen infrastructure.

The key problem is hydrogen storage, ever since we found that carbon nanotubes were spectacularly useless as storing hydrogen there just hasn’t been enough convincing progress on this issue. Compare this to what has been happening in batteries where everyone from A123 to Altair have been applying nanomaterials to produce lighter and faster charging batteries and you can understand the DoE shifting its priorities from the clean tech equivalent of nuclear fusion to something a bit more tangible.

If we want a longer term research project, I’d back using synthetic biology to produce a renewable source of petrol. The current proposals to add noises to electric vehicles to stop people sneaking up on blind people and squashing them is as ridiculous as vegetarian bacon when you can have the full throated roar of a V8 instead.

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