Migrating Buckyballs

Luna's Trimetaspheres

Arrowhead Research announced today that it had sold off the IP of one of its subsidiaries, Tego, to Luna Innovations in exchange for $430,000 less legal and transaction fees in exchange for a cut of any proceeds. Luna of course have been looking at buckyballs for improved MRI contrast agents – careful here! it’s a tricky subject –  for quite a while using the wonderfully named trimetaspheres.

The basic idea is great. You can take a nasty toxic substance such as gadolinium that happens to show up very well in MRI scans, and encase it in a fullerene cage so that all the patients body sees is carbon. However as with much to do with fullerenes, producing anything that works at a cost that is even vaguely competitive tends to be far tougher that originally envisaged.

So what we are seeing is an ongoing migration of various bits of nanotech IP towards companies that can turn them into a useful application. This particular bit of IP came from Carbon Nanotechnologies Inc whose plans for global domination included hoovering up every bit of carbon related IP they could fund and worrying what to do with it later.

 

Within weeks of nanotechnology becoming hot news, most of the nanotech related top level domains had been snapped in the expectation that a trillion dollar industry would emerge faster than you could say dot.com. Bored with waiting for a pay off, many are now up for grabs. The folks at nanovip.com are unloading their list of hopefuls after failing to attract any interest in nanosuccess.com. Anyone wanting a nano brand or domain will already have one by now, and it looks so 2001! The full list is here.

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The Wall Street Journal points to further evidence of the collapse of Venture Capital.  Typical of the doom laden quotes is this:

“Dallas is an entrepreneurial city, but it won’t be driven by venture capital going forward,” said Daniel T. Owen, a venture capitalist at the 16th-floor firm H02 Partners, which plans to wind down its venture business over the next few years. “The pure venture-capital model is really thriving in just Silicon Valley and Boston.”

The bottom line is, in this case the bottom line, as VCs who haven’t managed to make any money for their investors are left bemused by the unwillingness of anyone else to hand over cash. I’m bemused as to whether that’s an arrogant or stupid view of the world.

Toto, This isn’t 1997 any more!

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Nature published an interesting paper at the weekend, a Canadian meta study into public attitudes to nanotechnology. The key finding is that “those who perceive greater benefits outnumber those who perceive greater risks by 3 to 1.” That’s probably not too surprising, as the majority of press stories about nanotechnology tend to be along the lines of it curing cancer or making things better and/or more useful, but it’s nice to have some confirmation of this.

Michael Todd has some more thoughts on this, with the usual headline that the results are ’surprising’ – I’m not sure that they are.

The researchers also found that “a large minority of those surveyed (44%) is unsure” – which once again correlates with my London based experience which suggests that around 50% of people who work in electrical superstores or man call centres don;t have a clue what they are talking about, but manage to form an opinion nonetheless (the exception to this rule seems to be builders and plumbers merchants who not only know exactly what they are talking about but show Herculean patience when dealing with lesser mortals.)

In a nutshell then, people don’t mind nanotechnology, or any other technology too much if they perceive that it will have a positive impact on their daily lives, and will put up with a modicum of risk in order to enjoy the benefits. A bit like a chicken crossing the road then.

 

With a heavy heart I predicted a few high profile nanotechnology failures this year, and Evident Technologies are the latest to file for Chapter 11 bankruptcy protection. In common with Oxonica, Evident found themselves in a patent infringement fight with someone with deeper pockets then them, in this case Life Technologies (formerly Invitrogen) who got into the business by acquiring Quantum Dot Corporation back in 2005. The court costs were so high it pushed Evident over the edge. Losing their CEO earlier in the year probably didn’t help either.

There’s a nice contrast between the two litigants here, and one that illustrates the problems involved in getting a technology to market. In the case of the troubled companies, Oxonica and Evident, the strategy was based on first figuring out how to produce a nanomaterial and then trying to find a market for it. While both companies have made sales, neither has ever had quite enough volume to cross the chasm and become a sustainable business. Life Technologies, in contrast, pursued an acquisition strategy that netted them entry to other markets, and nanotechnology is just a part of their business rather than the whole of it.

There is a valuable lesson here, which is to start with the market, not the technology. In the early stages of a technology when investors are bullish a technology led strategy may work, but diversifying as quickly as possible is the key to survival.

 

It’s interesting that IBM seems to be the partner of choice for a number of nanotechnology in emerging economies such as Bulgaria and Egypt, (where there are large number of vacancies, including the post of “Centre Director.”)

IBM, as we all know, was responsible for the STM/AFM and holds a wide variety of nanotechnology related patents, including some fairly fundamental ones on carbon nanotubes. Partnering with these new centers allows IBM to double dip by providing services (now the core business) and encourage the exploitation of its patents – something that looks like a pretty smart strategy to me.

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Zettacore Change Tack

Interesting to see Zettacore raising a $21m series C, some six years after they first started our promising to replace silicon with molecular memories, although that’s not the application that is attracting interest right now.

As Nikkei Electronics reported last week – they look to have a customer for their Molecular Interface (aren’t most interfaces molecular?) technology that helps with conventional semiconductor manufacturing. While their initial plan for global domination of the memory business seems to have been elbowed aside with the fall in price of flash memory from a dollar a Mb 2001 to less than a dollar a Gb 2009, the R&D does seem to have been useful for something…

ZettaCore said MI technology enables deposition of copper on smooth dielectric, and lamination of dielectric on smooth copper in high-performance IC substrates, HDI boards, high-speed boards, flexible PCBs, and wafer level packaging. Since surface roughening is eliminated, customers can realize finer line/space dimensions and improve signal integrity while using conventional materials and processes.

“ZettaCore MI technology offers IC substrate customers the ability to leverage their manufacturing infrastructure and yet realize finer line/space design rules. For example, customers can advance interconnect geometries with the current GX-13 material beyond what is possible with conventional roughening technologies. Since the interfaces are smooth, losses related to skin effect are minimized which would improve system performance,” said Takao Sakurai, general manager of Specialty Chemical Dept, Ajinomoto Co Inc.

By working with Ajinomoto, ZettaCore is offering a complete and seamless solution to substrate manufacturers.

“Ajinomoto GX-13 build-up resin has a dominant market share in flip-chip IC substrates. Customers can now realize 10µm line/space design rules and beyond by using ZettaCore MI technology in conjunction with GX-13 material,” said Srinivas Nimmagadda, VP of Business Development at ZettaCore.

That’s another set of rebels assimilated into the world of CMOS then.

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An interesting battle is brewing over the hydrogen economy with the Obama administration doubting that fuel cells will make much of a difference over the next ten years to be worth funding and describing the decision as a reduction of “less effective programs so we can invest in our economic future.”

Honda, Toyota & General Motors have grumbled bitterly about this as all three have invested heavily in fuel cell research and have a vested interest in the US Government putting up the billions needed to develop a hydrogen infrastructure.

The key problem is hydrogen storage, ever since we found that carbon nanotubes were spectacularly useless as storing hydrogen there just hasn’t been enough convincing progress on this issue. Compare this to what has been happening in batteries where everyone from A123 to Altair have been applying nanomaterials to produce lighter and faster charging batteries and you can understand the DoE shifting its priorities from the clean tech equivalent of nuclear fusion to something a bit more tangible.

If we want a longer term research project, I’d back using synthetic biology to produce a renewable source of petrol. The current proposals to add noises to electric vehicles to stop people sneaking up on blind people and squashing them is as ridiculous as vegetarian bacon when you can have the full throated roar of a V8 instead.

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china-vs-worldA few years ago I spent a long time explaining to journalists that it didn’t actually matter whether Europe, the US or Japan was spending the most on nanotechnology R&D, it was how they spent it that mattered. But of course numbers and league tables make good copy.

Looking at the 2009 numbers, which you can see on the left or download directly here, things have changed a bit. It’s now a top five rather than a top three, and once we correct the numbers for purchasing power parity (PPP) which takes into account the fact that scientists are a lot cheaper in China than the US (although an electron microscope will cost about the same) the US has slipped from being undisputed world champion in 2001 to racing neck & neck with China for a bronze medal in 2009, while Russia and the EU are racing ahead.

But how much money you have to spend on anything is no indication of success, it’s what you do with it that matters, and that is the real story behind the numbers. Money can be wisely invested, stashed under the bed or frittered away in the pub, and we see all three strategies being deployed in the world of nanotechnologies.

Perhaps the most remarkable change is that from curiousity driven science to attempting to tackle some major issues. We’ll probably see that in the forthcoming Technology Strategy Board nanotechnology policies, and the US, India and China have already started thinking of nanotech as a tool to tackle some real and urgent issues rather than just something that goes on in a lab.

 

I received an email from the US NanoBusiness Alliance (yes they are still limping along) appealing for data on jobs created by nanotechnologies, a clear case of the hype that came back to bite.

We Need Your Jobs Data

During the Public Policy Tour, we received an assignment from Senator Wyden, Tom Kalil, and several other champions of nanotechnology: in order to make the best case for nanotechnology that they can, they need jobs information from you.  Nanotechnology businesses are among the few that are hiring, and our champions want to be able to show this.  We also need anecdotes that Senators and Members of Congress can use to personalize the data – specific instances in which you are hiring people, and the impact that you are having in your communities. In the days ahead, we will be asking you to participate in a survey that will help provide this important information.

There is an an obvious need to build a case for the Senators showing that nanotechnology has created jobs, but has it? Well if you take the preferred measure of the NanoBusiness Alliance, the “Nanotechnology Industry” then i rather suspect that the number of sustainable jobs created will be under a thousand, as most “nanotech companies” seem to subsist on SBIR and DARPA grants without showing any signs of real growth.

However if we want to look at the number of jobs created by nanotechnologies then it;s a different story – GMR and the associated precision manufacturing using focused ion beams which is used in hard disks enabled the iPod, which enable a whole new industry! The same is true in composites, pharmeceuticals, textiles and many other industry sectors, but the thing the Senators were promised by the NBA was a “nanotechnology industry.”

As far back as 2002 the NBA was getting its wrists slapped for coming with with stupid and naive predictions about the size of the ‘nanotechnology industry‘. As a comparison, I have added below the conclusion of an article I wrote for European Business Forum in 2003 disagreeing with the premise of their ever being a “nanotechnology industry.”

It is those stupid and naive predictions, the hype driven by a craving for attention that are now coming back to bite the NBA.  You can imagine the awkward scene:

“Ok guys, we bought in ten years ago, we gave you the cash so show us the results? How many jobs were created?”

“erm, let me send out an email and ask”

“So, just how big is the nanotechnology industry these days?

“erm, well, there were a couple of dozen nanotech companies but a few closed down, it’s the recession y’know”

“But back in 2002 you put out a report saying there were over a hundred and it would be worth $700 billion by last year”

“erm, erm…”

Well the lesson for today, ladies and gentlemen, is it doesn’t matter whether you are hyping nanotech or running a Ponzi scheme, if you can’t deliver and you stick around too long you’ll get caught out. Most of the early nanotech boosters are now boosting clean tech, or synthetic biology, or geoengineering. While not many of them have a clue what they are talking about, at least they had enough sense to skedaddle before any of the predictions came true.

The tragedy of course, is that the tens of thousands of scientists engaged in nanoscience weren’t the ones who made those silly predictions, and weren’t the ones who egged on organisations such as the NBA to come out with ever more preposterous predictions, but will be tarred with the same brush as the boosters by the politicians.

Nourishing the roots of innovation: nanotechnology is not a disruptive force in itself, but its effect on existing products will be.

Tim Harper, 2003

A major difference between almost every historically disruptive technology and nanotechnology is that there is no focal point. In previous diffusions there is a clear path of adoption and displacement–whether water with steam, vacuum tubes with transistors or transistors with integrated circuits–based on a dominant technology. Of course no technology stands alone, so the house of cards that allows integrated circuits to exist spans polymers to metrology, but there the processing of silicon is a dominant technology. That focus has allowed the semiconductor industry to be defined, and measured. There is no nanotechnology industry, and probably never will be.

While nanotechnology can act as a magnet for funding, in terms of measuring the impact of technology, it is no more a meaningful definition than that of chemistry (the science of matter; the branch of the natural sciences dealing with the composition of substances and their properties and reactions). Our understanding of chemistry has enabled many of the world’s largest industries, but it was never embraced in the 1920s by investors and the public as the next big thing.

Perhaps a better example is our understanding of quantum mechanics, initiated by the discovery of the electron in 1897. The understanding that allows us to control the movement of electrons, initially along copper wire, and later through other materials such as silicon, has affected almost every aspect of our lives. From the light bulb to the cellphone we are ruled by quantum effects, yet no one would point to the diffusion of our understanding of the quantum realm as a disruptive technology.

So how do we track the diffusion of a technology we cannot define? Put simply, we can’t. Few consumers or even businesses give too much time to how things work, as long as they do, and they work better than the previous generation, or those of their competitors. Fundamental understanding is the job of quantum physicists and now nanotechnologists.

The answer is to look beyond nanotechnology, and to look at its effect on existing technologies. The three billion dollars of government funding worldwide has been mostly pouring into academic establishments, and the increase in our understanding of the molecular scale that it is enabling is already finding commercial applications. Business can already make use of the tools developed by academic nanoscience research to gain more insight into processes we already have some control over, whether in using nanocatalysis to improve yield and boost margins at an oil refinery, or using nanofibres to sell stain resistant clothing at a premium.

We are undergoing a period of massively parallel technological development, enabled not only by nanotechnology but also by the convergence of all branches of science. While nanotechnology may be the next big thing as far as governments and scientists are concerned, the applications will be far bigger and none of them will be called nanotechnology.

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