There are two different approaches to Nanotechnology in Drug Delivery,  making drug crystals smaller to increase solubility and bioavailability, or using some form of carrier to deliver them in a more effective manner.

If we look at the total market size in 2021, it is a 60/40 split in favour of drug nano crystals although we feel that developing new delivery mechanisms may allow more value to be created.

The best performing nano carriers are shaping up to be:

  1. Liposomes  (28%);
  2. Gold Nanocarriers (17%);
  3. Dendrimers  (17%);
  4. Micelles (11%);
  5. Polymer-based Nanocarriers (5%);
  6. Nanoshells  (2%);
  7. Ceramic Nanocarriers (<1%);
  8. Calcium phosphate Nanocarriers (<1%).

 


Cientifica Ltd published Nanotechnology in Drug Delivery 2011  on 2 November 2011. Here’s a few of the key findings.

 

MARKET ANALYSIS BY KEY TECHNOLOGY

 

Of All Key Technologies Studied…

An analysis of the Total Addressable Market (TAM) in 2010, for nanotechnology in drug delivery (NDD), all key technologies studied shows the following values in 2010 (by descending order):

  1. Drug Nanocrystals (596 US$ Million Dollars), (45%);
  2. Total Nanocarriers (434 US$ Million Dollars), (32%);
  3. Targeted Delivery (178 US$ Million Dollars), (13%);
  4. Solubility + Bioavailability (139 US$ Million Dollars), (10%).

 

Nanocarriers as a Whole…

An analysis of the TAM in 2010, for NDD, nanocarriers as a whole shows the top 5 nanocarriers TAM values in 2010 as follows (by descending order):

  1. Liposomes (118 US$ Million Dollars), (28%);
  2. Dendrimers (84 US$ Million Dollars), (19%);
  3. Micelles (63 US$ Million Dollars), (15%);
  4. Gold Nanocarriers (56 US$ Million Dollars), (13%);
  5. CNTs (56 US$ Million Dollars), (13%).

 

Nanocarriers Versus Drug Nanocrystals…

Regarding total nanocarriers versus drug nanocrystals, drug nanocrystals show a higher TAM value in 2010, when compared with total nanocarriers:

  • Drug Nanocrystals (596 US$ Million Dollars), (58%);
  • Total Nanocarriers (434 US$ Million Dollars), (42%).

 

So, how advanced is NDD now? Which trends are being designed to 2021? Where will be opportunities for investment? Reading Nanotechnology in Drug Delivery 2011 will answer to these questions and many more and explain why?

Each time an individual suffers a heart attack and survives, unfortunately something happens to the heart permanently: some of the cells that constitute this organ die. Those cells can be:

These dead tissues give to the heart muscles weakening. Consequently, the heart becomes weaker and more vulnerable to future recurrent heart attacks.

Every year, hundreds of thousands of patients worldwide are believed to suffer from heart attacks related to the weakness caused by weakened heart muscle due to a previous heart attack.

The scientist Bikramjit Basu (Indian Institute of Technology, Kanpur, India) and scientists at Brown University in the USA carried out studies employing nanotechnology to create small synthetic nanostructures with the capability of regenerating those two different types of natural tissue cells of the heart that have died in previous heart attacks (cardiomyocites and neurons in the wall of the heart).

Those scientists used a polymer to attach carbon nanotubes (CNTs) helical-shaped, generating these way nanofibers. Those studies demonstrated that when the nanofibers were seeded with natural heart tissue cells, five times as many cells colonized the surface within four hours.

Those findings are presently yet to be submitted to tests through clinical trials. This work was published in the Acta Biomaterialia.

The relevance of these studies carried out by the scientist Bikramjit Basu (Indian Institute of Technology, Kanpur, India) and researchers at Brown University in the USA lies in the following benefits:

  • They have created the very first fix for resuscitating dead heart tissues in the world;
  • An approach was discovered that can help millions of heart attack patients avoid a recurrent heart attack. This highly ingenious and meritorious work will open doors for a dramatic reduction in repeated heart attacks;
  • These studies, once optimized, promise a quick and very effective therapy of the damaged heart;
  • This work will also open wide doors to significant progresses in the adoption of nanotechnology in regenerative medicine and tissue engineering.

Regarding the last benefit presented, it is important to enhance some of the breakthroughs that can be made in the future, unleashed by these and other studies:

At last weeks Nanotechnology for High performance Motorsport meeting, one of the participants, from a Formula One team, commented that he thought the current FIA regulations precluded the use of nanomaterials.

A bit of digging around in the current regulations (thanks to Chris Walker for unearthing this) only finds the following prohibition on using carbon nanotubes incorporated within carbon fibres, although given the difficulty of making an accurate distinction between nanotubes, nanofibres and carbon fibre it would be interesting to know which definition the is FIA using.

Carbon fibres manufactured from polyacrylonitrile (PAN) precursor which have :

-            a tensile modulus ? 550GPa ;

-            a density ? 1.92 g/cm3 ;

-            unidirectional or planar reinforcement within their pre-impregnated form, not including three dimensional weaves or stitched fabrics (but fibre reinforcement using Z-pinning technology is permitted) ;

-            no carbon nanotubes incorporated within the fibre or its matrix ;

-            a permitted matrix, not including a carbon matrix.

As far as I know, nanotechnology was used in the 2009 season, with McLarens KERS system using A123s nano phosphate lithium ion batteries as a result of their combination of weight and charge/discharge capacity. It certainly seems that other than the specific regulation above, there are no limits to what can be applied, and the ingenuity of motorsport engineers is second to none.

Of course were anyone except Ferrari to gain a substantial technical advantage from nanotechnology we may see the regulations being tweaked, but in general this is done to close loopholes that the use of novel materials may allow engineers to exploit, rather than to ban a whole technology.

Tagged with: batteriescarbon nanotubesformula one
 

A recent poll by the UK charity the Mental Health Foundation found that 77% of people found the world more frightening than in 1999, and put some of the blame on the “worst-case-scenario language” sometimes used by politicians, pressure groups, businesses and public bodies.

It does seem to be true that to get any kind of (media) attention you have to conjure up an apocalyptic scenario in order to be heard. It permeates every area of life, at least in Britain, requiring the most implausible scenarios to be given equal attention to more mundane ones.

While setting up a recent retail venture I needed to rent a shop and get it spruced up. Normally one would think that getting a  few quotes from painters and decorators and choosing a  colour scheme would be enough to get things moving, but not any more. In a five page ‘pre-approval checklist” the landlord (a bank) requires a full and separate fire and health and safety assessments to be carried out before we can even start work.

This means paying a  few hundred pounds for a bloke with a  clipboard to come round to take a look, and then write an official report stating that in the event of a fire, shoppers should be evacuated through the front and back doors and should under no circumstances grab all the teaspoons and attempt to tunnel out via the basement.  The health and safety assessment will no doubt consider actions to be taken if a decorator falls off a ladder, mistakenly drinks a gallon of floor paint.

Hopefully the health and safety assessment of the health and safety assessor will have considered what course of action to take in the rather more likely event of getting a paint brush jammed up his backside by an angry builder.

Equally ludicrous is the fear that nanotechnology may be the next asbestos by a variety of lawyers and trade unionists in Australia who seem to have missed the debate we had on this four of five years ago. Public debate of nanotechnologies in Australia seems to involve a lot of shouting, swearing and storming out of meetings and we can now add attempting to terrify people with half truths to that mix.

Let’s be quite clear, carbon nanotubes are long thin filaments that have the potential to behave like asbestos in certain circumstances and depending on the length of the nanotube, but that is the only similarity, and a glance at a brief history of asbestos shows why, but here is a key difference.

When asbestos began to be widely used in the 1870′s there were no electron microscopes capable of understanding the structure of the material, it was simply some useful stuff. In the 1990′s when carbon nanotubes began to be analysed the appearance of long filaments led researchers to immediately question whether that material could behave likes asbestos and as a result huge amounts of money have been spent on environmental health and safety studies of nanomaterials ever since. Asbestos had been widely used for a hundred years before anyone thought about health and safety.

Even so, the risk posed by a material is related to its chances of a sufficient quantity of it being ingested, which is why asbestosis tended to affect people working with asbestos and producing air borne dust such as  miners, builders etc rather than people simply living in a building containing it.

But asbestos was widely used because it was cheap, whereas nanomaterials are phenomenally expensive. You would have to be crazy to build a roof with carbon nanotubes, it would be cheaper to use bricks made from compressed cocaine, and anyway it wouldn’t work. For most nanomaterials you have to mix them with something else, a polymer of a resin to form any kind of structure, otherwise all you have is a bag of dust, and once those materials are embedded in a composite it is highly unlikely that they will ever be inhaled.

This is a rather simplistic treatment of the whole nano safety issue, and for more in depth information SafeNano is a good place to start. I’d suggest all the lawyers sniffing fat fees from future class action suits and dreaming of running ads like the one below pop along to SafeNano too. I usually pay my lawyers on the understanding that they know what they are taking about, or at least can get expert advice. I certainly wouldn’t use a law firm that puts out scare stories and half truths to try to win business, isn’t that illegal?

“If you or a loved one has suffered from exposure to nanoparticles or other nanomaterials, you may qualify for damages or remedies that may be awarded in a possible class action lawsuit. Please click the link below to submit your complaint and we will have a lawyer review your Nanotechnology complaint.”

So when we look at any emerging technology, the 21st century situation is very different from that of the 1930′s. the last fifty years have seen huge advances in all sciences, from physics to toxicology, and the use if computing means that there is no reason for any researcher to be ignorant of anyone else’s results. Many of the mistakes made with materials in the past were due to ignorance of the structure of the material and its interaction with the environment. Now we have a huge array of tools to probe the structure of matter, and a massive and accessible body of knowledge of past mistakes to draw on, whether the toxic effects caused by the chirality of drug molecules or the structure of materials asbestosis, all available with a few clicks of a mouse.

There is really no need for anyone to be ignorant any more, scientists or lawyers.

Technology Review has a piece on Unidym’s conducting nanotube films and how they are about to hit the market.

Given the recent news about consolidation, and cash problems, that market can’t come too soon.

Tagged with: Arrowheadcarbon nanotubesCNTNanotechnanotechnologiesunidym
 

The Great CNT Fire Sale – Continued

On January 18, 2009, in Nanotech, by Tim

More nanomaterials woes, this time from Unidym who you may recall bought Carbon Nanotechnology Inc’s  and CSixty’s IP for a song a few years ago. We’ve herard of big job cuts and this comes from the annual report of their parent, Arrowhead Research Corporation. It can be read along the lines of desperate cash starved company mortgages its future to Tokyo Electron in exchange for a couple of million bucks.

Unidym raised a total of $14 million of equity financing in fiscal 2008. In fiscal 2008, Unidym consumed large amounts of cash to scale up the manufacture of carbon nanotubes, scale up for the production and sale its first carbon nanotube based film product, acquire another nanotech company, expand its business development activities, and prepare for an initial public offering. In the first and second quarters of fiscal 2008, Unidym expanded its executive, technical and administrative staff for these activities. Unidym’s cash burn ramped from $2 million in the second quarter, $3.6 million in the third quarter and $4.2 million in the fourth quarter.

In the fourth quarter, it was clear that Unidym would be unable to meet its fund raising goals to support its 2009 cash needs. Moreover, technical development took longer than expected. Additionally, it became evident that dramatic change in the financial market would not allow an initial public offering. Starting in October 2008, several general and administrative positions were eliminated. Approximately, half of its team in its Houston, TX facility was put on unpaid leave to conserve cash. Further cuts to personnel and consolidation of facilities are planned to bring Unidym’s cash burn to 60% of its high water mark in fourth quarter 2008. However, Unidym will still need to obtain additional cash to fund its operations and obligations through fiscal 2009.

What is particularly depressing about this story is that the IP in question all came from the lab of Richard Smalley, one of the founding fathers of nanotechnology. So far it’s taken some $40 million to get, erm, nowhere. One day I’ll get around to adding up all the money spent on taking nanomaterials to market, it must be close to half a billion by now.

Tagged with: Arrowheadcarbon nanotubesCNICNTCSixtydesperate measuresNanotechTokyo Electronunidym